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When CBD reaches a family of receptors, or cells that receive stimuli, called vanilloid receptors, the interaction results in lower inflammation and levels and pain perception, according to a study published in Current Neuropharmacology. And a study published in July 2016 in the European Journal of Pain found that CBD could help people with arthritis manage their pain. The animal study looked at whether using a CBD gel transdermally (on the skin) would reduce inflammation and signs of pain, and researchers concluded that the topical product did offer relief from pain-related behaviors without evidence of side effects.
Anxiety and depression
Hundreds of studies have looked at how cannabidiol might be used to treat various neuropsychiatric disorders. One of the most recent, published in October 2015 in Neurotherapeutics, concluded that topical CBD has “considerable potential as treatment for multiple anxiety disorders.” What’s more, a study review published in September 2015 in the Journal of the American Society for Experimental NeuroTherapeutics found that “preclinical evidence strongly supports CBD as a treatment for anxiety disorders,” including PTSD, generalized anxiety disorders, obsessive-compulsive disorder, and seasonal affective disorder.
Anecdotal reports about CBD’s use as a treatment for epilepsy have been around for decades, and a handful of rigorous scientific studies seem to support these claims. One, published in May 2018 in the New England Journal of Medicine, showed CBD to be effective at reducing the number of seizures in people with a form of epilepsy called Lennox–Gastaut syndrome (LGS). And in 2018, the FDA approved an oral CBD formulation for LGS and another type of epilepsy called Dravet syndrome.
Acne and other skin issues
A study published in July 2014 in the Journal of Clinical Investigation suggested topical CBD can be a potent antiacne agent, likely because of its anti-inflammatory properties. And a study published in July 2017 in the Journal of the American Academy of Dermatology found CBD (and THC) useful for reducing the itch and inflammation associated with eczema and psoriasis.
High blood pressure
Researchers in England studied the effects of CBD on a small group of healthy men ages 19 to 29 — all nonsmokers who had never used cannabis — and discovered a single dose of CBD reduced resting blood pressure by 6 millimeters of mercury (mmHg), which may ultimately also reduce the risk of stroke. The study, published in July 2017 in JCI Insight, concluded that the response may be due to CBD’s anxiolytic (anxiety-reducing) and analgesic (pain-reducing) effects.
As ironic as it sounds, CBD — which technically is classified as a Schedule I substance by the Drug Enforcement Administration and as such is currently illegal in nearly half the United States — has shown a lot of promise in fighting addiction to everything from opioids and cocaine to alcohol and tobacco. In addition, a number of preclinical studies, including a study published in June 2017 in Cannabis and Cannabinoid Research, suggest CBD might be useful as a pain therapy in place of opioids.
A number of studies, including one published in February 2012 in the American Journal of Pathology, have suggested that CBD could play a role in improving outcomes for people with diabetes. Observational studies have shown that people who use marijuana have lower fasting insulin levels and measures of insulin resistance.